CEPAC: Cost Effectiveness of Preventing AIDS Complications
Since 1994, the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) team, led by Dr. Kenneth Freedberg at the Massachusetts General Hospital, has used simulation models to evaluate clinical outcomes, costs, and cost-effectiveness of strategies for treating HIV/AIDS and its complications. The model, first developed with a focus in the US epidemic, has grown over time in both scope and application to provide comprehensive analyses for testing and treatment strategies for HIV/AIDS and AIDS-related complications, including tuberculosis and other infections.
The CEPAC team collaborates with research teams in Côte d’Ivoire, France, India, South Africa, and Zimbabwe, as well as investigators from Brigham and Women’s Hospital, the Harvard School of Public Health, Weill Cornell Medical College, and Yale University. Research from the CEPAC team has been published in leading medical journals, including the New England Journal of Medicine, Journal of the American Medical Association, Annals of Internal Medicine, and AIDS. CEPAC manuscripts have been among the top 10 studies of the year at both the National Institute of Allergy and Infectious Diseases and the National Institute of Mental Health. In December of 2008, the team won the Partners in Excellence award for Outstanding Teamwork.
Last Updated (Monday, 08 February 2010 10:46)
-
March 01, 2010
Publication
Gregory Robbins and CEPAC-US investigators published an article in Clinical Infectious Diseases. This paper uses data captured in the electronic health record to develop a prediction rule for virologic failure among patients being treated for HIV infection. Click here for the abstract. -
February 16, 2010
CROI 2010
CEPAC investigators presented at the 17th Conference on Retroviruses and Opportunistic Infections in San Francisco, CA with 2 abstracts:
Test and Treat: Forecasting the Clinical and Epidemiological Impact of Expanded HIV Screening and Immediate ART in Sub-Saharan Africa. First Author: Callie Scott
Strong Association between Medication Possession Ratio and Early Virological Outcomes in Adults on ART in Côte d'Ivoire. First Author: Eugène Messou -
February 01, 2010
Publication
Melissa Bender and CEPAC-International collaborators published an article in Clinical Infectious Diseases. This paper evaluates the clinical outcomes and cost-effectiveness of first-line ART using tenofovir in India, compared with the current practice of using stavudine or zidovudine. Click here for the abstract. -
January 24, 2010
Publication
Ingrid Bassett and CEPAC-International investigators published an article in AIDS. This paper evaluate rates of antiretroviral therapy initiation within 12 months of a new HIV diagnosis in Durban, South Africa. Click here for the abstract. -
January 15, 2010
Publication
Rochelle Walensky published a Viewpoint in Clinical Infectious Diseases. This piece addresses the substantial impact the President's Emergency Plan for AIDS Relief (PEPfAR) has achieved in general and more specifically toward improving maternal and child health and why continued PEPfAR investment remains essential. Click here for the abstract. -
December 15, 2009
Publication
Andrea Ciaranello and co-authors published an article in Clinical Infectious Diseases. This paper uses a literature review and meta-analysis to derive estimates of the virologic suppression and CD4 cell gain for children initiating ART in resource-limited settings. Click here for the abstract. -
November 30, 2009
Publication
Ishani Ganguli and members of the CEPAC team published an article in Current HIV/AIDS Reports. This paper reviews the mechanisms and literature to date of home-based HIV testing strategy in resource-limited settings. Click here for the abstract. - Read all news items...