Since 1994, the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) team, led by Drs. Kenneth Freedberg and Rochelle Walensky at the Massachusetts General Hospital, has used simulation models to evaluate clinical outcomes, costs, and cost-effectiveness of strategies for treating HIV/AIDS and its complications. The model, first developed with a focus in the US epidemic, has grown over time in both scope and application to provide comprehensive analyses for testing and treatment strategies for HIV/AIDS and AIDS-related complications, including tuberculosis and other infections.


The CEPAC team collaborates with research teams in Botswana, Brazil, Côte d’Ivoire, France, India, Mozambique, South Africa, and Zimbabwe, as well as investigators from Brigham and Women’s Hospital, the Harvard School of Public Health, Weill Cornell Medical College, and Yale University. Research from the CEPAC team has been published in leading medical journals, including the New England Journal of Medicine, Journal of the American Medical AssociationAnnals of Internal Medicine, and AIDS.  CEPAC manuscripts have been among the top 10 studies of the year at both the National Institute of Allergy and Infectious Diseases and the National Institute of Mental Health.